EHBP1

Across TCGA patient cohorts, EHBP1 mutation is significantly associated with the total protein of many other genes, with 59 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EHBP1-associated genes across cancer lineages are FASN, 14-3-3_beta, and eEF2. Each is linked with EHBP1 in more than 3 cancer types. Because this analysis shows association rather than direction, both EHBP1-to-partner and partner-to-EHBP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FASN grouped by EHBP1-low versus EHBP1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EHBP1→partner) and Y-score (partner→EHBP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	FASN →	+0.573	+3.330	.001	.005	3	4
UCEC	14-3-3_beta →	-0.097	-2.221	.001	.001	3	3
UCEC	eEF2 →	+0.260	+1.807	.013	.024	3	3
UCEC	GAPDH →	+0.404	+1.999	.010	.008	3	3
UCEC	ATM →	-0.610	-2.369	<.001	<.001	3	3
UCEC	c-Met_pY1235 →	+0.046	+1.161	.036	.032	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 59 associations by consensus.

FASN by EHBP1 expression — COAD

Explore this box plot interactively →