EFS

Across TCGA patient cohorts, EFS mutation is significantly associated with the RNA expression of many other genes, with 1,212 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EFS-associated genes across cancer lineages are ATAD3A, RNU6-1082P, and RGS17P1. Each is linked with EFS in more than 1 cancer types. Because this analysis shows association rather than direction, both EFS-to-partner and partner-to-EFS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATAD3A grouped by EFS-low versus EFS-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EFS→partner) and Y-score (partner→EFS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATAD3A →	+0.588	+3.346	.001	.005	3	2
UCEC	RNU6-1082P →	+0.280	+3.229	<.001	.001	3	2
UCEC	RGS17P1 →	+0.322	+2.670	.006	.005	3	2
UCEC	RPL32P32 →	+0.655	+2.638	<.001	.005	3	2
UCEC	RORA-AS1 →	+0.373	+3.492	<.001	.002	3	2
LUAD	ULK3 →	+0.644	+3.217	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,212 associations by consensus.

ATAD3A by EFS expression — UCEC

Explore this box plot interactively →