EFS

Across TCGA pan-cancer cohorts, EFS RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of EFS’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where EFS RNA is repressed in tumor relative to normal tissue. In most cancer types EFS is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

KICH, THCA, and COAD are the cancer types where EFS tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in EFS RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	III,IV	−2.983	<.001	11	view →
THCA	Male	All	−1.078	<.001	9	view →
COAD	All	II,III,IV	−0.702	<.001	8	view →
KIRP	Male	II,III,IV	−2.154	<.001	7	view →
KIRC	Male	II,III,IV	−0.837	<.001	7	view →
UCEC	All	III,IV	−2.845	<.001	6	view →
LUSC	Female	All	+1.817	<.001	6	view →
STAD	All	All	−1.260	.002	5	view →
BRCA	Female	All	−0.497	<.001	4	view →
READ	Female	All	−1.556	.010	2	view →
PRAD	All	All	−1.282	<.001	2	view →
LUAD	Male	III,IV	−1.204	.009	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

EFS–KICH

Open the KICH breakdown →