EFS

Across TCGA pan-cancer cohorts, EFS RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated EFS data layer compared with 6 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher EFS RNA is associated with better overall survival. In most high-consensus cancer types, elevated EFS expression acts as an unfavorable survival marker, although some lineages such as UVM and UCS show a favorable association.

UVM, UCS, and BRCA are the cancer types where EFS RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Median	All	0.838	0.372	<.001	132	view →
UCS	OS	Tertile	II,III,IV	0.697	0.203	.001	86	view →
BRCA	OS	Quartile	III,IV	0.850	0.970	<.001	57	view →
UCEC	DFS	Tertile	IV	0.974	0.535	.001	42	view →
ACC	OS	Quartile	II,III,IV	0.357	0.897	.002	40	view →
LGG	OS	Median	All	0.878	0.738	<.001	36	view →
KIRP	DFS	Tertile	II,III,IV	0.310	0.734	.007	33	view →
STAD	OS	Quartile	II,III,IV	0.523	0.715	.009	31	view →
LUSC	OS	Quartile	II,III,IV	0.808	0.624	.004	25	view →
GBM	DFS	Median	All	0.393	0.186	.001	24	view →
MESO	OS	Median	All	0.289	0.679	.006	23	view →
CHOL	DFS	Quartile	All	0.790	0.164	.007	21	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

EFS–UVM (OS)

Open the UVM breakdown →