EFS

Across TCGA patient cohorts, EFS mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EFS-associated genes across cancer lineages are eEF2, Ku80, and ATM. Each is linked with EFS in more than 1 cancer types. Because this analysis shows association rather than direction, both EFS-to-partner and partner-to-EFS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by EFS-low versus EFS-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EFS→partner) and Y-score (partner→EFS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.507	+2.459	.003	.020	3	2
UCEC	Ku80 →	+0.305	+2.472	.007	.011	3	2
UCEC	ATM →	-0.626	-2.986	.004	.035	3	2
UCEC	EGFR_pY1068 →	-0.365	-3.169	.002	.019	3	1
UCEC	ACC1 →	+0.440	+3.013	.012	.018	3	1
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.634	+3.009	.009	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

eEF2 by EFS expression — UCEC

Explore this box plot interactively →