EFS

Across TCGA cell cohorts, EFS RNA expression is significantly associated with the go_rna of many other GO terms, with 3,006 significant associations in total. BONE shows the largest number of these associations.

The most reproducible EFS-associated GO terms across cancer lineages are Positive regulation of cytoplasmic translation, Transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery, and Cadmium ion transport. Each is linked with EFS in more than 8 cancer types. Because this analysis shows association rather than direction, both EFS-to-partner and partner-to-EFS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of cytoplasmic translation grouped by EFS-low versus EFS-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (EFS→partner) and Y-score (partner→EFS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Positive regulation of cytoplasmic translation →	+0.105	+2.435	<.001	.004	2	9
BLOOD_Lymphoma	Transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery →	+0.082	+0.025	<.001	.006	3	7
BONE	Cadmium ion transport →	-0.100	-2.213	.002	.003	3	7
BONE	Cadmium ion transmembrane transport →	-0.100	-2.213	.002	.003	3	7
OESOPHAGUS	Regulatory ncRNA-mediated gene silencing →	+0.079	+2.472	.002	.002	2	7
LUNG_SCLC	Negative regulation of RNA splicing →	+0.085	+2.735	<.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,006 associations by consensus.

Positive regulation of cytoplasmic translation by EFS expression — LUNG_SCLC

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