EFS

Across TCGA cell cohorts, EFS mutation is significantly associated with the RNA expression of many other genes, with 20 significant associations in total. CNS shows the largest number of these associations.

The most reproducible EFS-associated genes across cancer lineages are LHCGR, ZNF705D, and C14orf177. Each is linked with EFS in more than 1 cancer types. Because this analysis shows association rather than direction, both EFS-to-partner and partner-to-EFS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LHCGR grouped by EFS-low versus EFS-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EFS→partner) and Y-score (partner→EFS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	LHCGR →	+0.090	+3.836	.002	.004	3	2
OESOPHAGUS	ZNF705D →	+0.062	+3.836	<.001	.004	3	2
BLOOD_Leukemia	C14orf177 →	+0.114	+4.922	<.001	.009	3	1
BLOOD_Leukemia	HELT →	+0.019	+5.969	<.001	.001	3	1
STOMACH	URAD →	+0.141	+3.280	.007	.004	3	1
SKIN	HPGDS →	+0.057	+3.823	.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

LHCGR by EFS expression — OESOPHAGUS

Explore this box plot interactively →