EFL1

Across TCGA patient cohorts, EFL1 mutation is significantly associated with the total protein of many other genes, with 39 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EFL1-associated genes across cancer lineages are S6_pS240_S244, BRCA2, and C-Raf. Each is linked with EFL1 in more than 2 cancer types. Because this analysis shows association rather than direction, both EFL1-to-partner and partner-to-EFL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, S6_pS240_S244 grouped by EFL1-low versus EFL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EFL1→partner) and Y-score (partner→EFL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	S6_pS240_S244 →	+0.273	+1.222	.038	.035	3	3
COAD	BRCA2 →	+0.293	+3.169	.011	.019	3	2
COAD	C-Raf →	+0.191	+3.178	.007	.010	3	2
UCEC	EGFR_pY1068 →	-0.237	-3.087	.003	<.001	3	2
UCEC	JNK_pT183_Y185 →	-0.116	-1.415	.034	.043	3	2
UCEC	Akt_pT308 →	+0.431	+2.000	.035	.029	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

S6_pS240_S244 by EFL1 expression — UCEC

Explore this box plot interactively →