EFL1

Across TCGA pan-cancer cohorts, EFL1 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of EFL1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where EFL1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types EFL1 is over-expressed in tumor, although a few such as COAD show the opposite, repressed pattern.

HNSC, LIHC, and KIRP are the cancer types where EFL1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in EFL1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+0.775	<.001	12	view →
LIHC	All	III,IV	+0.752	<.001	9	view →
KIRP	All	II,III,IV	+0.485	<.001	8	view →
KIRC	Male	All	+0.378	<.001	8	view →
STAD	All	II,III,IV	+0.555	.003	6	view →
BRCA	All	II,III,IV	+0.323	<.001	6	view →
CHOL	Male	All	+1.598	<.001	5	view →
LUSC	All	All	+0.393	<.001	5	view →
UCEC	All	III,IV	+0.735	.005	4	view →
COAD	Female	All	−0.511	.008	4	view →
BLCA	All	All	+0.441	.023	3	view →
ESCA	All	All	+0.772	.014	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

EFL1–HNSC

Open the HNSC breakdown →