EFEMP1

Across TCGA patient cohorts, EFEMP1 mutation is significantly associated with the RNA expression of many other genes, with 5,012 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EFEMP1-associated genes across cancer lineages are RPL17P51, RNU6-940P, and RN7SL134P. Each is linked with EFEMP1 in more than 2 cancer types. Because this analysis shows association rather than direction, both EFEMP1-to-partner and partner-to-EFEMP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPL17P51 grouped by EFEMP1-low versus EFEMP1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EFEMP1→partner) and Y-score (partner→EFEMP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RPL17P51 →	+0.248	+2.223	<.001	.005	3	3
LUSC	RNU6-940P →	+0.222	+4.993	<.001	.003	3	3
LUSC	RN7SL134P →	+0.204	+4.417	<.001	.002	3	3
UCEC	TCP11X3P →	+0.181	+1.532	.001	.002	3	3
SKCM	RN7SKP43 →	+0.219	+2.989	<.001	.003	3	3
PRAD	LINC02174 →	+0.079	+7.939	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,012 associations by consensus.

RPL17P51 by EFEMP1 expression — SKCM

Explore this box plot interactively →