EFEMP1

Across TCGA pan-cancer cohorts, EFEMP1 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of EFEMP1’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where EFEMP1 RNA is repressed in tumor relative to normal tissue. In most cancer types EFEMP1 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

THCA, KICH, and LUSC are the cancer types where EFEMP1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in EFEMP1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	III,IV	−4.029	<.001	11	view →
KICH	Female	All	−3.429	<.001	10	view →
LUSC	Female	All	−2.585	<.001	9	view →
LUAD	Female	III,IV	−2.322	<.001	9	view →
UCEC	All	All	−4.016	<.001	8	view →
BLCA	Male	All	−3.244	<.001	8	view →
COAD	Female	II,III,IV	−1.429	<.001	7	view →
BRCA	All	II,III,IV	−2.045	<.001	6	view →
KIRP	All	All	−1.703	<.001	6	view →
KIRC	Male	II,III,IV	−0.867	.005	5	view →
CHOL	Female	All	+4.383	<.001	2	view →
READ	Female	All	−1.956	.009	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

EFEMP1–THCA

Open the THCA breakdown →