EDC4

Across TCGA patient cohorts, EDC4 mutation is significantly associated with the RNA expression of many other genes, with 5,187 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EDC4-associated genes across cancer lineages are SSRP1, PBK, and SEH1L. Each is linked with EDC4 in more than 3 cancer types. Because this analysis shows association rather than direction, both EDC4-to-partner and partner-to-EDC4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SSRP1 grouped by EDC4-low versus EDC4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EDC4→partner) and Y-score (partner→EDC4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SSRP1 →	+0.447	+2.717	<.001	<.001	3	4
UCEC	PBK →	+0.935	+2.203	<.001	<.001	3	4
UCEC	SEH1L →	+0.442	+2.007	<.001	<.001	3	4
UCEC	NOB1 →	+0.444	+2.102	<.001	<.001	3	4
UCEC	EME1 →	+0.453	+1.747	.001	<.001	3	3
UCEC	SFXN1 →	+0.560	+1.736	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,187 associations by consensus.

SSRP1 by EDC4 expression — UCEC

Explore this box plot interactively →