EDAR

Across TCGA patient cohorts, EDAR RNA expression is significantly associated with the protein abundance of many other proteins, with 11,468 significant associations in total. GBM shows the largest number of these associations.

The most reproducible EDAR-associated proteins across cancer lineages are TRIM29, DPYD_S905, and LRRFIP1. Each is linked with EDAR in more than 4 cancer types. Because this analysis shows association rather than direction, both EDAR-to-partner and partner-to-EDAR results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, EDAR versus TRIM29 in BRCA, with a Pearson correlation of 0.51.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (EDAR→partner) and Y-score (partner→EDAR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	TRIM29 →	+0.975	+0.392	<.001	.001	3	5
GBM	DPYD_S905 →	-0.757	-0.267	<.001	<.001	3	5
CCRCC	LRRFIP1 →	-0.300	-0.632	<.001	.001	3	4
CCRCC	SEC24A →	-0.306	-0.549	<.001	<.001	3	4
HNSC	TBX2_S360 →	+0.529	+0.937	.002	.001	3	4
UCEC	VSNL1 →	+1.724	+2.107	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,468 associations by consensus.

EDAR vs TRIM29 — BRCA

Explore this scatter interactively →