EDAR

Across TCGA patient cohorts, EDAR protein abundance is significantly associated with the RNA expression of many other genes, with 503 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible EDAR-associated genes across cancer lineages are SNW1, CHGA, and PRPF6. Each is linked with EDAR in more than 1 cancer types. Because this analysis shows association rather than direction, both EDAR-to-partner and partner-to-EDAR results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, EDAR versus SNW1 in LSCC, with a Pearson correlation of -0.46.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EDAR→partner) and Y-score (partner→EDAR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SNW1 →	-0.401	-1.152	.009	.005	3	1
LSCC	CHGA →	-1.298	-1.664	<.001	.002	3	1
LSCC	PRPF6 →	-0.667	-1.973	.008	.003	3	1
LSCC	COL20A1 →	-0.111	-1.668	.001	.003	3	1
LSCC	NAA10 →	-0.317	-1.622	.007	<.001	3	1
LSCC	UBL4A →	-0.685	-1.318	.003	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 503 associations by consensus.

EDAR vs SNW1 — LSCC

Explore this scatter interactively →