EDAR

Across TCGA patient cohorts, EDAR mutation is significantly associated with the RNA expression of many other genes, with 3,827 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EDAR-associated genes across cancer lineages are AIMP1, MAPKAPK5-AS1, and PREPL. Each is linked with EDAR in more than 3 cancer types. Because this analysis shows association rather than direction, both EDAR-to-partner and partner-to-EDAR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AIMP1 grouped by EDAR-low versus EDAR-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EDAR→partner) and Y-score (partner→EDAR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	AIMP1 →	+0.425	+3.021	<.001	<.001	3	4
UCEC	MAPKAPK5-AS1 →	+0.451	+3.180	<.001	<.001	3	4
SKCM	PREPL →	+0.512	+3.510	.009	.002	3	4
LGG	MTCO2P30 →	+0.128	+3.237	.002	.005	3	3
UCEC	DCP1A →	+0.407	+1.930	.008	.009	3	3
SKCM	ADCY6 →	+0.625	+1.932	.002	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,827 associations by consensus.

AIMP1 by EDAR expression — UCEC

Explore this box plot interactively →