EDAR

Across TCGA patient cohorts, EDAR mutation is significantly associated with the total protein of many other genes, with 40 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EDAR-associated genes across cancer lineages are FoxM1, PCNA, and eIF4E. Each is linked with EDAR in more than 2 cancer types. Because this analysis shows association rather than direction, both EDAR-to-partner and partner-to-EDAR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by EDAR-low versus EDAR-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EDAR→partner) and Y-score (partner→EDAR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.213	+1.584	.036	.036	3	3
UCEC	PCNA →	+0.322	+2.807	<.001	.003	3	3
UCEC	eIF4E →	+0.239	+2.807	.003	.003	2	3
SKCM	eIF4G →	+0.325	+2.321	.035	.033	3	2
SKCM	p90 RSK →	+0.176	+2.321	.032	.032	3	2
SKCM	c-Kit →	-0.639	-2.000	.012	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

FoxM1 by EDAR expression — UCEC

Explore this box plot interactively →