EDAR

Across TCGA cell cohorts, EDAR RNA expression is significantly associated with the go_rna of many other GO terms, with 2,689 significant associations in total. URINARY_TRACT shows the largest number of these associations.

The most reproducible EDAR-associated GO terms across cancer lineages are Pericardium morphogenesis, Glycerol transmembrane transport, and Mesonephros development. Each is linked with EDAR in more than 7 cancer types. Because this analysis shows association rather than direction, both EDAR-to-partner and partner-to-EDAR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Pericardium morphogenesis grouped by EDAR-low versus EDAR-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (EDAR→partner) and Y-score (partner→EDAR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Pericardium morphogenesis →	+1.547	+1.478	<.001	.007	3	8
URINARY_TRACT	Glycerol transmembrane transport →	+1.864	+1.153	<.001	<.001	3	7
URINARY_TRACT	Mesonephros development →	+0.063	+0.893	.003	.005	3	7
URINARY_TRACT	Mesonephric epithelium development →	+0.076	+0.942	.001	.003	3	7
URINARY_TRACT	Mesonephric tubule development →	+0.076	+0.942	.001	.003	3	7
STOMACH	Regulation of pro-B cell differentiation →	+0.132	+2.327	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,689 associations by consensus.

Pericardium morphogenesis by EDAR expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →