EDA2R

Across TCGA patient cohorts, EDA2R mutation is significantly associated with the RNA expression of many other genes, with 2,718 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EDA2R-associated genes across cancer lineages are RN7SL248P, RPS29P32, and IGHD5-12. Each is linked with EDA2R in more than 2 cancer types. Because this analysis shows association rather than direction, both EDA2R-to-partner and partner-to-EDA2R results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL248P grouped by EDA2R-low versus EDA2R-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EDA2R→partner) and Y-score (partner→EDA2R) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RN7SL248P →	+0.057	+3.078	<.001	.001	3	3
UCEC	RPS29P32 →	+0.302	+1.947	<.001	.003	3	2
LUAD	IGHD5-12 →	+1.112	+3.322	.003	.001	3	2
LUAD	RNU6ATAC33P →	+0.187	+4.912	<.001	<.001	3	2
UCEC	KIF15 →	+0.711	+2.601	<.001	<.001	3	2
UCEC	RPUSD4 →	+0.402	+1.960	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,718 associations by consensus.

RN7SL248P by EDA2R expression — UCEC

Explore this box plot interactively →