EDA2R

Across TCGA pan-cancer cohorts, EDA2R RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of EDA2R’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where EDA2R RNA is more highly expressed in tumor relative to normal tissue. In most cancer types EDA2R is over-expressed in tumor, although a few such as LUSC and BRCA show the opposite, repressed pattern.

KIRC, KIRP, and LUSC are the cancer types where EDA2R tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in EDA2R RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	All	+2.142	<.001	12	view →
KIRP	Female	II,III,IV	+3.048	<.001	11	view →
LUSC	All	III,IV	−1.291	<.001	9	view →
THCA	Male	All	+1.129	<.001	8	view →
LIHC	All	II,III,IV	+0.797	<.001	8	view →
BRCA	Female	All	−0.802	<.001	6	view →
UCEC	All	All	−1.326	<.001	4	view →
COAD	Female	II,III,IV	−0.425	.004	4	view →
CHOL	All	All	+2.027	<.001	3	view →
BLCA	Male	All	−0.915	.016	2	view →
PRAD	All	All	−0.573	<.001	2	view →
READ	Female	All	−0.810	.048	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

EDA2R–KIRC

Open the KIRC breakdown →