EDA

Across TCGA patient cohorts, EDA mutation is significantly associated with the RNA expression of many other genes, with 4,481 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EDA-associated genes across cancer lineages are CTLA4, CRTAM, and CD80. Each is linked with EDA in more than 3 cancer types. Because this analysis shows association rather than direction, both EDA-to-partner and partner-to-EDA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CTLA4 grouped by EDA-low versus EDA-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EDA→partner) and Y-score (partner→EDA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CTLA4 →	+0.631	+1.753	<.001	<.001	3	4
UCEC	CRTAM →	+0.337	+1.669	<.001	<.001	3	3
UCEC	CD80 →	+0.176	+1.576	.007	<.001	3	3
UCEC	KLRD1 →	+0.202	+1.710	.002	<.001	3	3
UCEC	TLR4 →	+0.517	+1.481	.003	.003	3	3
UCEC	TIGIT →	+0.583	+1.887	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,481 associations by consensus.

CTLA4 by EDA expression — UCEC

Explore this box plot interactively →