EDA

Across TCGA pan-cancer cohorts, EDA RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of EDA’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where EDA RNA is repressed in tumor relative to normal tissue. In most cancer types EDA is over-expressed in tumor, although a few such as LUAD and BLCA show the opposite, repressed pattern.

LUAD, BLCA, and BRCA are the cancer types where EDA tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in EDA RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	All	III,IV	−1.101	<.001	9	view →
BLCA	Male	III,IV	−1.705	<.001	6	view →
BRCA	All	All	−0.883	<.001	6	view →
THCA	Male	III,IV	−1.697	<.001	5	view →
LUSC	All	All	−0.581	<.001	5	view →
CHOL	All	II,III,IV	+1.300	<.001	4	view →
LIHC	Female	All	+1.196	<.001	3	view →
KICH	Female	II,III,IV	+1.082	.009	3	view →
COAD	Male	IV	−1.045	<.001	3	view →
READ	Male	All	−0.809	.042	2	view →
KIRP	Female	II,III,IV	+0.762	.040	2	view →
KIRC	Female	All	+0.384	.042	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

EDA–LUAD

Open the LUAD breakdown →