EDA

Across TCGA cell cohorts, EDA mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible EDA-associated genes across cancer lineages are OR1L3, OR4E1, and C18orf63. Each is linked with EDA in more than 1 cancer types. Because this analysis shows association rather than direction, both EDA-to-partner and partner-to-EDA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR1L3 grouped by EDA-low versus EDA-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EDA→partner) and Y-score (partner→EDA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	OR1L3 →	+0.022	+5.169	<.001	.005	3	1
BREAST	OR4E1 →	+0.150	+5.781	<.001	.001	3	1
BLOOD_Lymphoma	C18orf63 →	+0.012	+4.867	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

OR1L3 by EDA expression — BREAST

Explore this box plot interactively →