ECPAS

Across TCGA patient cohorts, ECPAS mutation is significantly associated with the total protein of many other genes, with 53 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ECPAS-associated genes across cancer lineages are 4E-BP1, GAPDH, and TFRC. Each is linked with ECPAS in more than 3 cancer types. Because this analysis shows association rather than direction, both ECPAS-to-partner and partner-to-ECPAS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by ECPAS-low versus ECPAS-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ECPAS→partner) and Y-score (partner→ECPAS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.338	+1.784	<.001	<.001	3	4
UCEC	GAPDH →	+0.328	+1.765	.031	.011	3	4
UCEC	TFRC →	+0.530	+3.169	<.001	<.001	3	4
UCEC	eIF4E →	+0.169	+1.784	.004	<.001	3	3
UCEC	FASN →	+0.249	+1.247	.026	.041	3	3
UCEC	PRDX1 →	+0.137	+1.415	.019	.040	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 53 associations by consensus.

4E-BP1 by ECPAS expression — UCEC

Explore this box plot interactively →