Across TCGA patient cohorts, ECI2 mutation is significantly associated with the RNA expression of many other genes, with 578 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ECI2-associated genes across cancer lineages are RNA5-8SP7, HSBP1P1, and TRAJ47. Each is linked with ECI2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ECI2-to-partner and partner-to-ECI2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ECI2→partner) and Y-score (partner→ECI2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RNA5-8SP7 →	+0.238	+6.357	<.001	<.001	3	2
SKCM	HSBP1P1 →	+0.173	+2.915	.003	.008	3	2
KIRP	TRAJ47 →	+0.440	+5.103	<.001	.004	3	2
BLCA	SNX18P8 →	+0.028	+4.229	<.001	.006	3	2
BLCA	RNA5SP73 →	+0.236	+3.577	.003	.001	3	2
HNSC	UQCR10P1 →	+0.375	+4.320	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 578 associations by consensus.

Exploration

ECI2 survival (RNA) · tumor vs normal (RNA) · all ECI2 data types