ECD

Across TCGA patient cohorts, ECD mutation is significantly associated with the RNA expression of many other genes, with 911 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ECD-associated genes across cancer lineages are PPARA, ZNF724, and CDK7P1. Each is linked with ECD in more than 1 cancer types. Because this analysis shows association rather than direction, both ECD-to-partner and partner-to-ECD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PPARA grouped by ECD-low versus ECD-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ECD→partner) and Y-score (partner→ECD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PPARA →	+0.397	+2.098	.007	.003	3	2
UCEC	ZNF724 →	+0.569	+2.230	.002	.006	3	2
UCEC	CDK7P1 →	+0.181	+2.116	.003	.008	3	2
UCEC	TMX2P1 →	+0.649	+3.343	.003	.005	3	2
KIRP	RNU6-665P →	+0.674	+4.457	<.001	.005	3	2
BLCA	RNA5SP149 →	+0.585	+4.588	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 911 associations by consensus.

PPARA by ECD expression — UCEC

Explore this box plot interactively →