ECD

Across TCGA pan-cancer cohorts, ECD RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of ECD’s most consistent transcriptional readouts.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where ECD RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ECD is over-expressed in tumor, although a few such as KICH and KIRP show the opposite, repressed pattern.

LIHC, KICH, and LUAD are the cancer types where ECD tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ECD RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LIHC	Female	II,III,IV	+1.129	<.001	9	view →
KICH	Female	II,III,IV	−1.608	<.001	8	view →
LUAD	Male	II,III,IV	+0.527	<.001	7	view →
COAD	Male	All	+0.367	<.001	6	view →
BRCA	All	II,III,IV	+0.290	<.001	6	view →
HNSC	All	All	+0.264	.005	5	view →
STAD	All	II,III,IV	+0.540	.002	4	view →
CHOL	All	All	+1.710	<.001	3	view →
ESCA	All	II,III,IV	+0.464	.017	3	view →
LUSC	All	All	+0.233	.003	3	view →
READ	Male	All	+0.413	.047	2	view →
KIRP	Male	All	−0.265	.032	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

ECD–LIHC

Open the LIHC breakdown →