ECD

Across TCGA cell cohorts, ECD mutation is significantly associated with the RNA expression of many other genes, with 52 significant associations in total. CNS shows the largest number of these associations.

The most reproducible ECD-associated genes across cancer lineages are IL18RAP, PSMA8, and DDX53. Each is linked with ECD in more than 1 cancer types. Because this analysis shows association rather than direction, both ECD-to-partner and partner-to-ECD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IL18RAP grouped by ECD-low versus ECD-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ECD→partner) and Y-score (partner→ECD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	IL18RAP →	+0.109	+3.758	<.001	.007	3	1
SOFT_TISSUE	PSMA8 →	+0.131	+4.459	<.001	.001	3	1
SOFT_TISSUE	DDX53 →	+0.380	+3.865	<.001	.006	3	1
SOFT_TISSUE	MGAT4D →	+0.004	+4.392	<.001	.004	3	1
PANCREAS	OR6V1 →	+0.019	+5.000	<.001	.006	3	1
URINARY_TRACT	HAO1 →	+0.060	+4.217	.007	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 52 associations by consensus.

IL18RAP by ECD expression — SOFT_TISSUE

Explore this box plot interactively →