EAPP

Across TCGA patient cohorts, EAPP mutation is significantly associated with the RNA expression of many other genes, with 86 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EAPP-associated genes across cancer lineages are RNY4P3, MIR107, and MIR4769. Each is linked with EAPP in more than 1 cancer types. Because this analysis shows association rather than direction, both EAPP-to-partner and partner-to-EAPP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNY4P3 grouped by EAPP-low versus EAPP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EAPP→partner) and Y-score (partner→EAPP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNY4P3 →	+0.337	+2.833	.004	.006	3	2
LUSC	MIR107 →	+0.417	+4.978	<.001	.005	3	2
SKCM	MIR4769 →	+0.288	+4.614	<.001	.006	3	2
BRCA	H3P46 →	+0.193	+7.731	<.001	.009	3	1
BRCA	MIR3689D2 →	+0.552	+8.055	<.001	.007	3	1
BRCA	MIR4780 →	+0.458	+8.471	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 86 associations by consensus.

RNY4P3 by EAPP expression — UCEC

Explore this box plot interactively →