EAPP

Across TCGA pan-cancer cohorts, EAPP RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of EAPP’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where EAPP RNA is repressed in tumor relative to normal tissue. In most cancer types EAPP is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

KICH, THCA, and LIHC are the cancer types where EAPP tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in EAPP RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	All	−1.047	<.001	9	view →
THCA	Male	IV	−0.576	<.001	9	view →
LIHC	All	II,III,IV	+0.490	<.001	9	view →
COAD	Female	All	−0.676	<.001	8	view →
READ	All	All	−0.625	.009	4	view →
UCEC	All	All	−0.600	<.001	4	view →
HNSC	All	III,IV	+0.360	.009	3	view →
CHOL	All	All	+1.049	<.001	2	view →
LUSC	Male	III,IV	−0.697	.008	2	view →
KIRC	All	II,III,IV	−0.268	.005	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

EAPP–KICH

Open the KICH breakdown →