E2F7

Across TCGA patient cohorts, E2F7 RNA expression is significantly associated with the protein abundance of many other proteins, with 21,624 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible E2F7-associated proteins across cancer lineages are RFC2, RRM2, and SMC2. Each is linked with E2F7 in more than 9 cancer types. Because this analysis shows association rather than direction, both E2F7-to-partner and partner-to-E2F7 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, E2F7 versus RFC2 in LSCC, with a Pearson correlation of 0.72.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (E2F7→partner) and Y-score (partner→E2F7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	RFC2 →	+0.505	+1.120	<.001	<.001	3	10
LUAD	RRM2 →	+0.922	+0.931	<.001	<.001	3	10
UCEC	SMC2 →	+0.709	+1.394	<.001	<.001	3	10
LSCC	SMC4 →	+0.622	+1.057	<.001	<.001	3	10
LUAD	CHAF1B_S410 →	+0.874	+0.914	<.001	<.001	3	10
LSCC	FEN1 →	+0.530	+0.909	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 21,624 associations by consensus.

E2F7 vs RFC2 — LSCC

Explore this scatter interactively →