E2F7

Across TCGA pan-cancer cohorts, E2F7 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of E2F7’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where E2F7 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types E2F7 is over-expressed in tumor.

HNSC, BLCA, and COAD are the cancer types where E2F7 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in E2F7 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	All	+2.064	<.001	12	view →
BLCA	Male	III,IV	+2.441	<.001	11	view →
COAD	Female	II,III,IV	+1.405	<.001	11	view →
KIRC	Male	All	+0.728	<.001	11	view →
LUAD	Male	II,III,IV	+1.380	<.001	9	view →
KIRP	All	III,IV	+1.164	<.001	9	view →
THCA	All	III,IV	+0.296	<.001	9	view →
LUSC	Female	All	+3.047	<.001	8	view →
STAD	Male	II,III,IV	+1.685	<.001	8	view →
LIHC	Male	All	+0.810	<.001	8	view →
READ	All	All	+1.235	<.001	7	view →
UCEC	All	III,IV	+2.613	<.001	6	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

E2F7–HNSC

Open the HNSC breakdown →