E2F3

Across TCGA cell cohorts, E2F3 mutation is significantly associated with the RNA expression of many other genes, with 20 significant associations in total. OVARY shows the largest number of these associations.

The most reproducible E2F3-associated genes across cancer lineages are FREM3, CCDC182, and PRSS54. Each is linked with E2F3 in more than 1 cancer types. Because this analysis shows association rather than direction, both E2F3-to-partner and partner-to-E2F3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FREM3 grouped by E2F3-low versus E2F3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (E2F3→partner) and Y-score (partner→E2F3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	FREM3 →	+0.109	+4.054	.004	.004	3	2
SOFT_TISSUE	CCDC182 →	+0.037	+4.369	<.001	.008	3	1
LARGE_INTESTINE	PRSS54 →	+0.046	+3.930	<.001	.003	3	1
LARGE_INTESTINE	OR10W1 →	+0.019	+4.562	<.001	<.001	3	1
LARGE_INTESTINE	OR10Q1 →	+0.110	+3.920	.001	.005	3	1
LARGE_INTESTINE	C14orf180 →	+0.198	+4.155	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

FREM3 by E2F3 expression — LARGE_INTESTINE

Explore this box plot interactively →