E2F3

Across TCGA pan-cancer cohorts, E2F3 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated E2F3 data layer compared with 4 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher E2F3 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated E2F3 expression acts as an unfavorable survival marker, although some lineages such as BLCA and SCLC show a favorable association.

KIRP, MESO, and LIHC are the cancer types where E2F3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	DFS	Tertile	All	0.740	0.941	<.001	103	view →
MESO	OS	Quartile	All	0.209	0.557	<.001	68	view →
LIHC	DFS	Median	All	0.457	0.622	<.001	66	view →
ACC	DFS	Tertile	All	0.357	0.718	<.001	51	view →
SARC	DFS	Median	All	0.405	0.624	<.001	36	view →
COAD	OS	Median	All	0.724	0.877	.002	34	view →
BLCA	DFS	Quartile	III,IV	0.526	0.141	<.001	34	view →
SCLC	DFS	Median	IV	0.651	0.148	.006	28	view →
SKCM	DFS	Tertile	III,IV	0.356	0.776	<.001	25	view →
READ	OS	Quartile	II,III,IV	1.000	0.852	.009	17	view →
LGG	OS	Median	All	0.850	0.966	<.001	15	view →
GBM	DFS	Tertile	All	0.477	0.198	.001	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

E2F3–KIRP (DFS)

Open the KIRP breakdown →