Across TCGA patient cohorts, E2F3-IT1 RNA expression is significantly associated with the protein abundance of many other proteins, with 13,920 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible E2F3-IT1-associated proteins across cancer lineages are TOP2A, TOP2A_S1247, and FANCI. Each is linked with E2F3-IT1 in more than 5 cancer types. Because this analysis shows association rather than direction, both E2F3-IT1-to-partner and partner-to-E2F3-IT1 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (E2F3-IT1→partner) and Y-score (partner→E2F3-IT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	TOP2A →	+0.763	+0.962	<.001	.002	3	6
LSCC	TOP2A_S1247 →	+0.992	+0.891	<.001	<.001	3	6
UCEC	FANCI →	+0.518	+0.883	.001	<.001	3	6
GBM	SETDB1_S1066 →	+0.897	+0.688	.003	<.001	3	6
LSCC	ATAD2_S342 →	+1.043	+0.861	<.001	<.001	3	5
LUAD	BRCA1_S114 →	+0.792	+0.588	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,920 associations by consensus.

Exploration

E2F3-IT1 survival (RNA) · tumor vs normal (RNA) · all E2F3-IT1 data types