E2F1

Across TCGA patient cohorts, E2F1 RNA expression is significantly associated with the protein abundance of many other proteins, with 23,565 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible E2F1-associated proteins across cancer lineages are TOP2A_S1247, TOP2A_S1377, and UNG_S23. Each is linked with E2F1 in more than 9 cancer types. Because this analysis shows association rather than direction, both E2F1-to-partner and partner-to-E2F1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, E2F1 versus TOP2A_S1247 in LUAD, with a Pearson correlation of 0.77.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (E2F1→partner) and Y-score (partner→E2F1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	TOP2A_S1247 →	+1.614	+1.389	<.001	<.001	3	10
LUAD	TOP2A_S1377 →	+1.222	+1.183	<.001	<.001	3	10
LSCC	UNG_S23 →	+1.034	+0.969	<.001	<.001	3	10
LUAD	PAICS_S27 →	+1.411	+1.125	<.001	<.001	3	10
OV	POLD1 →	+0.353	+0.860	<.001	<.001	3	10
LUAD	CDK1 →	+1.014	+1.402	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 23,565 associations by consensus.

E2F1 vs TOP2A_S1247 — LUAD

Explore this scatter interactively →