E2F1

Across TCGA pan-cancer cohorts, E2F1 RNA is linked to patient survival in 28 of 34 cancer types, making it the most broadly survival-associated E2F1 data layer compared with 5 for mutation status.

The strongest signal is observed in mesothelioma (MESO), where higher E2F1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated E2F1 expression acts as an unfavorable survival marker, although some lineages such as READ and THCA show a favorable association.

MESO, ACC, and KICH are the cancer types where E2F1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Median	All	0.374	0.697	<.001	138	view →
ACC	DFS	Median	All	0.247	0.647	<.001	128	view →
KICH	DFS	Median	III,IV	0.260	1.000	<.001	101	view →
KIRP	DFS	Tertile	All	0.817	0.956	<.001	86	view →
LIHC	DFS	Median	All	0.463	0.641	<.001	74	view →
PAAD	DFS	Tertile	All	0.186	0.421	<.001	62	view →
KIRC	DFS	Tertile	All	0.730	0.836	.004	53	view →
LGG	OS	Median	All	0.738	0.882	<.001	53	view →
UCEC	DFS	Median	All	0.776	0.898	<.001	40	view →
READ	DFS	Tertile	II,III,IV	1.000	0.587	.004	37	view →
CHOL	DFS	Median	All	0.198	0.666	<.001	34	view →
THCA	OS	Median	II,III,IV	1.000	0.796	.005	32	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 28 lineages.

E2F1–MESO (OS)

Open the MESO breakdown →