E2F1

Across TCGA patient cohorts, E2F1 mutation is significantly associated with the RNA expression of many other genes, with 1,381 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible E2F1-associated genes across cancer lineages are CSF2RA, PSAT1P4, and MTHFD2P3. Each is linked with E2F1 in more than 1 cancer types. Because this analysis shows association rather than direction, both E2F1-to-partner and partner-to-E2F1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CSF2RA grouped by E2F1-low versus E2F1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (E2F1→partner) and Y-score (partner→E2F1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CSF2RA →	+0.465	+1.914	.004	.009	3	2
UCEC	PSAT1P4 →	+0.109	+1.574	.003	.003	3	2
UCEC	MTHFD2P3 →	+0.100	+2.015	.008	.005	3	2
UCEC	RN7SL354P →	+0.142	+1.526	.005	.007	3	2
UCEC	GLA →	+0.399	+2.271	<.001	.005	3	2
SKCM	OR4M1 →	+0.045	+3.776	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,381 associations by consensus.

CSF2RA by E2F1 expression — UCEC

Explore this box plot interactively →