E2F1

Across TCGA cell cohorts, E2F1 mutation is significantly associated with the RNA expression of many other genes, with 21 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible E2F1-associated genes across cancer lineages are DEFB129, OR10V1, and P2RY13. Each is linked with E2F1 in more than 1 cancer types. Because this analysis shows association rather than direction, both E2F1-to-partner and partner-to-E2F1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DEFB129 grouped by E2F1-low versus E2F1-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (E2F1→partner) and Y-score (partner→E2F1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	DEFB129 →	+0.026	+4.437	<.001	.004	3	1
SKIN	OR10V1 →	+0.016	+4.437	<.001	.004	3	1
SKIN	P2RY13 →	+0.005	+3.684	<.001	.006	3	1
BLOOD_Leukemia	BTBD16 →	+0.094	+3.959	<.001	.005	3	1
BLOOD_Leukemia	CYP39A1 →	+0.253	+3.769	<.001	.008	3	1
BLOOD_Leukemia	UGT2B4 →	+0.060	+3.855	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

DEFB129 by E2F1 expression — SKIN

Explore this box plot interactively →