DYRK1A

Across TCGA patient cohorts, DYRK1A RNA expression is significantly associated with the protein abundance of many other proteins, with 12,601 significant associations in total. GBM shows the largest number of these associations.

The most reproducible DYRK1A-associated proteins across cancer lineages are SIN3A, HNRNPLL, and RSF1. Each is linked with DYRK1A in more than 4 cancer types. Because this analysis shows association rather than direction, both DYRK1A-to-partner and partner-to-DYRK1A results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, DYRK1A versus SIN3A in GBM, with a Pearson correlation of 0.43.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (DYRK1A→partner) and Y-score (partner→DYRK1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SIN3A →	+0.321	+0.317	<.001	<.001	3	5
HNSC	HNRNPLL →	+0.219	+0.335	.001	.002	3	5
LSCC	RSF1 →	+0.328	+0.344	<.001	<.001	3	4
GBM	HTATIP2 →	-0.555	-0.296	<.001	<.001	3	4
GBM	MORF4L1 →	+0.338	+0.318	<.001	.001	3	4
PDAC	NFYC →	+0.259	+0.237	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,601 associations by consensus.

DYRK1A vs SIN3A — GBM

Explore this scatter interactively →