DYRK1A

Across TCGA pan-cancer cohorts, DYRK1A RNA differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of DYRK1A’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where DYRK1A RNA is repressed in tumor relative to normal tissue. In most cancer types DYRK1A is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

THCA, KICH, and LIHC are the cancer types where DYRK1A tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DYRK1A RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	All	−0.544	<.001	9	view →
KICH	All	All	−0.734	<.001	6	view →
LIHC	All	All	+0.379	<.001	6	view →
CHOL	Male	All	+1.328	<.001	2	view →
UCEC	All	All	−0.412	.015	2	view →
KIRP	All	All	−0.389	.001	2	view →
HNSC	Female	All	+0.364	.045	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

DYRK1A–THCA

Open the THCA breakdown →