DYRK1A

Across TCGA patient cohorts, DYRK1A mutation is significantly associated with the RNA expression of many other genes, with 3,688 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DYRK1A-associated genes across cancer lineages are RNU6-628P, HMG20B, and ELOCP33. Each is linked with DYRK1A in more than 2 cancer types. Because this analysis shows association rather than direction, both DYRK1A-to-partner and partner-to-DYRK1A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-628P grouped by DYRK1A-low versus DYRK1A-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DYRK1A→partner) and Y-score (partner→DYRK1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	RNU6-628P →	+0.289	+2.499	.002	.007	3	3
UCEC	HMG20B →	+0.293	+1.834	.002	.001	3	3
LIHC	ELOCP33 →	+0.064	+4.233	.009	.003	3	2
BRCA	RNA5SP162 →	+0.499	+4.058	.001	.002	3	2
BRCA	RNA5SP413 →	+0.286	+5.556	<.001	.001	3	2
UCEC	TENM4 →	-0.478	-1.121	.007	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,688 associations by consensus.

RNU6-628P by DYRK1A expression — CESC

Explore this box plot interactively →