DUX4L26

Across TCGA patient cohorts, DUX4L26 RNA expression is significantly associated with the go_rna of many other GO terms, with 7,074 significant associations in total. STAD shows the largest number of these associations.

The most reproducible DUX4L26-associated GO terms across cancer lineages are Regulation of RNA export from nucleus, Translational initiation, and Positive regulation of stem cell population maintenance. Each is linked with DUX4L26 in more than 24 cancer types. Because this analysis shows association rather than direction, both DUX4L26-to-partner and partner-to-DUX4L26 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of RNA export from nucleus grouped by DUX4L26-low versus DUX4L26-high in DLBC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DUX4L26→partner) and Y-score (partner→DUX4L26) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
DLBC	Regulation of RNA export from nucleus →	+0.080	+0.141	.004	.003	3	25
STAD	Translational initiation →	+0.051	+0.270	<.001	<.001	3	25
ESCA	Positive regulation of stem cell population maintenance →	+0.068	+0.250	.001	<.001	3	24
ESCA	Positive regulation by host of viral genome replication →	+0.057	+0.333	.001	<.001	3	24
ESCA	Protein stabilization →	+0.049	+0.253	.004	<.001	3	24
THYM	Protein localization to lysosome →	+0.052	+1.363	<.001	<.001	3	24

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,074 associations by consensus.

Regulation of RNA export from nucleus by DUX4L26 expression — DLBC

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