DUX4L26

Across TCGA pan-cancer cohorts, DUX4L26 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated DUX4L26 data layer.

The strongest signal is observed in uterine carcinosarcoma (UCS), where higher DUX4L26 RNA is associated with better overall survival. In most high-consensus cancer types, elevated DUX4L26 expression acts as an unfavorable survival marker, although some lineages such as UCS and LIHC show a favorable association.

UCS, MESO, and LIHC are the cancer types where DUX4L26 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCS	OS	Tertile	III,IV	0.712	0.150	<.001	78	view →
MESO	OS	Median	All	0.289	0.489	.003	57	view →
LIHC	DFS	Median	III,IV	0.405	0.157	<.001	25	view →
CESC	DFS	Quartile	All	0.616	0.832	.001	24	view →
READ	DFS	Median	IV	0.393	0.820	.013	23	view →
BLCA	DFS	Median	All	0.163	0.505	.005	19	view →
LAML	DFS	Quartile	All	0.717	0.473	.016	18	view →
UCEC	DFS	Quartile	All	0.570	0.706	.003	14	view →
DLBC	DFS	Quartile	III,IV	0.077	1.000	.017	14	view →
PCPG	OS	Tertile	All	0.865	1.000	.017	12	view →
PAAD	DFS	Tertile	II,III,IV	0.541	0.339	.014	12	view →
KIRP	OS	Median	III,IV	0.886	0.629	.006	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

DUX4L26–UCS (OS)

Open the UCS breakdown →