DUX4L26

Across TCGA pan-cancer cohorts, DUX4L26 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of DUX4L26’s most consistent transcriptional readouts.

The strongest signal is observed in breast invasive carcinoma (BRCA), where DUX4L26 RNA is repressed in tumor relative to normal tissue. In most cancer types DUX4L26 is over-expressed in tumor, although a few such as BRCA and KICH show the opposite, repressed pattern.

BRCA, KICH, and KIRP are the cancer types where DUX4L26 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DUX4L26 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BRCA	All	III,IV	−0.285	<.001	6	view →
KICH	All	II,III,IV	−0.164	<.001	6	view →
KIRP	All	All	+0.285	.007	5	view →
KIRC	All	All	+0.151	.006	3	view →
UCEC	All	IV	−0.245	.016	2	view →
LUAD	All	All	+0.222	.004	2	view →
PRAD	All	All	−0.211	<.001	2	view →
HNSC	Female	II,III,IV	−0.189	.023	2	view →
THCA	All	All	−0.178	.010	2	view →
LIHC	All	All	+0.141	.021	2	view →
COAD	Male	II,III,IV	+0.094	.031	2	view →
CHOL	All	All	+0.373	.035	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

DUX4L26–BRCA

Open the BRCA breakdown →