DUSP6

Across TCGA patient cohorts, DUSP6 mutation is significantly associated with the RNA expression of many other genes, with 342 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DUSP6-associated genes across cancer lineages are SPCS2P2, RNA5SP442, and RN7SL147P. Each is linked with DUSP6 in more than 1 cancer types. Because this analysis shows association rather than direction, both DUSP6-to-partner and partner-to-DUSP6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SPCS2P2 grouped by DUSP6-low versus DUSP6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DUSP6→partner) and Y-score (partner→DUSP6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SPCS2P2 →	+0.064	+2.765	.001	.005	3	2
COAD	RNA5SP442 →	+0.563	+4.893	<.001	.005	3	2
UCEC	RN7SL147P →	+0.187	+2.591	.001	.002	3	2
UCEC	MIR5093 →	+0.262	+2.719	.007	.006	3	2
BLCA	SOX5P1 →	+0.208	+3.913	<.001	.002	3	2
UCEC	RN7SL714P →	+0.110	+3.115	.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 342 associations by consensus.

SPCS2P2 by DUSP6 expression — UCEC

Explore this box plot interactively →