DUSP6

Across TCGA pan-cancer cohorts, DUSP6 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated DUSP6 data layer compared with 3 for mutation status and 3 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher DUSP6 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated DUSP6 expression acts as an unfavorable survival marker, although some lineages such as UCEC and KIRC show a favorable association.

ACC, UCEC, and HNSC are the cancer types where DUSP6 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	OS	Median	All	0.645	0.936	<.001	111	view →
UCEC	DFS	Quartile	II,III,IV	0.925	0.731	<.001	90	view →
HNSC	OS	Quartile	All	0.569	0.739	<.001	81	view →
KIRP	DFS	Median	All	0.777	0.930	<.001	75	view →
KIRC	OS	Tertile	All	0.752	0.557	<.001	66	view →
PAAD	OS	Tertile	All	0.461	0.836	<.001	52	view →
LGG	OS	Median	All	0.742	0.874	<.001	42	view →
LUSC	DFS	Quartile	All	0.679	0.811	.007	34	view →
SKCM	OS	Quartile	All	0.387	0.225	<.001	33	view →
GBM	OS	Tertile	All	0.288	0.502	.002	27	view →
THCA	DFS	Tertile	All	0.951	0.731	.013	22	view →
MESO	DFS	Quartile	III,IV	0.605	0.301	.009	20	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

DUSP6–ACC (OS)

Open the ACC breakdown →