DUSP22

Across TCGA cell cohorts, DUSP22 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. BLOOD_Myeloma shows the largest number of these associations.

The most reproducible DUSP22-associated genes across cancer lineages are ESX1, CEACAM3, and KRTAP2-4. Each is linked with DUSP22 in more than 1 cancer types. Because this analysis shows association rather than direction, both DUSP22-to-partner and partner-to-DUSP22 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ESX1 grouped by DUSP22-low versus DUSP22-high in BLOOD_Myeloma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DUSP22→partner) and Y-score (partner→DUSP22) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	ESX1 →	+0.126	+4.807	<.001	.006	3	1
BLOOD_Myeloma	CEACAM3 →	+0.053	+4.807	<.001	.006	3	1
BLOOD_Myeloma	KRTAP2-4 →	+0.049	+4.807	<.001	.006	3	1
SKIN	MFRP →	+0.013	+4.684	.002	.002	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

ESX1 by DUSP22 expression — BLOOD_Myeloma

Explore this box plot interactively →