DUSP22

Across TCGA pan-cancer cohorts, DUSP22 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated DUSP22 data layer compared with 4 for mutation status and 7 for mass-spec protein.

The strongest signal is observed in mesothelioma (MESO), where higher DUSP22 RNA is associated with better overall survival. In most high-consensus cancer types, elevated DUSP22 expression acts as an unfavorable survival marker, although some lineages such as MESO and KIRC show a favorable association.

MESO, KIRC, and LUSC are the cancer types where DUSP22 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Median	All	0.679	0.413	<.001	90	view →
KIRC	OS	Tertile	All	0.708	0.524	.002	53	view →
LUSC	OS	Tertile	All	0.310	0.494	<.001	48	view →
UVM	OS	Median	II,III,IV	0.744	0.517	.011	45	view →
UCS	DFS	Quartile	II,III,IV	0.630	0.225	.017	34	view →
KICH	OS	Quartile	II,III,IV	0.566	1.000	.005	34	view →
COAD	DFS	Quartile	All	0.712	0.855	.001	26	view →
SARC	DFS	Quartile	All	0.653	0.366	<.001	26	view →
LIHC	OS	Quartile	All	0.375	0.642	.003	26	view →
CHOL	DFS	Tertile	All	0.717	0.230	.004	21	view →
ACC	DFS	Quartile	II,III,IV	0.331	0.792	.011	20	view →
LGG	OS	Quartile	All	0.347	0.552	.013	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

DUSP22–MESO (OS)

Open the MESO breakdown →