DUSP14

Across TCGA pan-cancer cohorts, DUSP14 RNA is linked to patient survival in 28 of 34 cancer types, making it the most broadly survival-associated DUSP14 data layer compared with 3 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher DUSP14 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated DUSP14 expression acts as an unfavorable survival marker, although some lineages such as ESCA and LUSC show a favorable association.

UVM, MESO, and ACC are the cancer types where DUSP14 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Median	All	0.416	0.879	<.001	117	view →
MESO	OS	Median	All	0.243	0.526	<.001	96	view →
ACC	DFS	Median	All	0.236	0.656	<.001	95	view →
BLCA	DFS	Tertile	All	0.192	0.566	<.001	94	view →
LIHC	OS	Tertile	All	0.694	0.861	<.001	82	view →
KIRP	DFS	Tertile	II,III,IV	0.569	0.911	.001	57	view →
KICH	OS	Tertile	II,III,IV	0.636	1.000	.007	50	view →
PAAD	OS	Tertile	All	0.282	0.635	<.001	43	view →
LGG	DFS	Median	All	0.661	0.817	<.001	43	view →
SKCM	OS	Tertile	All	0.268	0.421	<.001	39	view →
CHOL	DFS	Median	II,III,IV	0.121	0.626	.002	29	view →
LUAD	DFS	Tertile	All	0.212	0.710	.001	24	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 28 lineages.

DUSP14–UVM (OS)

Open the UVM breakdown →