DUS4L

Across TCGA cell cohorts, DUS4L RNA expression is significantly associated with the go_rna of many other GO terms, with 3,595 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible DUS4L-associated GO terms across cancer lineages are tRNA dihydrouridine synthesis, Positive regulation of isotype switching to IgG isotypes, and Regulation of telomeric D-loop disassembly. Each is linked with DUS4L in more than 18 cancer types. Because this analysis shows association rather than direction, both DUS4L-to-partner and partner-to-DUS4L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, tRNA dihydrouridine synthesis grouped by DUS4L-low versus DUS4L-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DUS4L→partner) and Y-score (partner→DUS4L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	tRNA dihydrouridine synthesis →	+0.137	+0.839	<.001	<.001	3	19
BONE	Positive regulation of isotype switching to IgG isotypes →	+0.129	+0.686	<.001	.001	3	15
SOFT_TISSUE	Regulation of telomeric D-loop disassembly →	+0.136	+0.747	<.001	<.001	3	12
PANCREAS	Regulation of isotype switching to IgG isotypes →	+0.100	+0.572	<.001	.001	3	11
SOFT_TISSUE	Telomere maintenance via telomerase →	+0.081	+0.461	<.001	.007	3	10
BLOOD_Lymphoma	Meiotic mismatch repair →	+0.083	+0.446	.002	.007	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,595 associations by consensus.

tRNA dihydrouridine synthesis by DUS4L expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →